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The ARDS Net protocol advocates for the use of low tidal volume ventilation, specifically targeting a tidal volume of 6 mL/kg of predicted body weight. This approach is pivotal in the management of Acute Respiratory Distress Syndrome (ARDS) as it has been shown to improve outcomes. By using a lower tidal volume, the risk of ventilator-induced lung injury is minimized, which is a significant concern in patients with ARDS due to their already compromised lung function.

The rationale behind this protocol is that lower tidal volumes prevent over-distension of alveoli and reduce the stress and strain on lung tissues, which can exacerbate injury. Studies have demonstrated that this strategy leads to improved mortality rates compared to traditional higher tidal volume strategies. Therefore, using a low tidal volume not only protects lung function but also enhances overall patient survival in the context of ARDS management.

In summary, the recommendation for a tidal volume of 6 mL/kg directly correlates to improved clinical outcomes and represents current best practices based on evidence garnered from large-scale clinical trials.